Tsc1fl/fl
WebFeb 3, 2015 · Insulin resistance is an important contributing factor in non-alcoholic fatty liver disease. AKT and mTORC1 are key components of the insulin pathway, and play a role in promoting de novo lipogenesis. However, mTORC1 hyperactivity per se does not induce steatosis in mouse livers, but instead, protects against high-fat diet induced steatosis. … WebTsc1fl/fl;Alb-Cre tissue 1: Sample type: SRA : Source name: liver tissue of Tsc1fl/fl;Alb-Cre mouse: Organism: Mus musculus: Characteristics: age: 320 days tissue: liver genotype: …
Tsc1fl/fl
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WebPhosphatidylinositide 3-kinase (PI3K) is deregulated in many human tumor types, including primary liver malignancies. The kinase v-akt murine thymoma viral oncogene homolog 1 (Akt) and mammalian target of rapamycin complex (mTORC1) are effectors of PI3K that promote cell growth and survival, but their individual roles in tumorigenesis are not well … WebAt 40 weeks of age, Pten fl/fl ;Alb cre (Pten-null) mice develop tumors that are physiologically similar to human HCCs and ICCs (intrahepatic cholangiocarcinoma) (Horie …
WebFeb 7, 2024 · Scientists at the University of Geneva (UNIGE) have been working on an alternative therapy based on the protein S100A9 for several years. (PHOTO CREDIT: Web9 hours ago · LOS ANGELES, April 14, 2024 /PRNewswire/ -- Aadi Bioscience, Inc. (NASDAQ: AADI), a commercial-stage biopharmaceutical company focused on developing and commercializing precision therapies for ...
WebFeb 6, 2024 · Control mice were injected with 1 × 10^9 PFU of adenovirus serotype 5 expressing GFP only: Tsc1fl/fl. b Plasma insulin levels of insulin-deficient mice and healthy controls (p = 0.0003 and p = 0.0001). C mRNA content of Tcs1 in liver (p = 0.0584) and skeletal muscle (gastrocnemius) of the indicated groups. (Credit: University of Geneva … WebJan 25, 2024 · E/I balance is skewed toward hyperexcitability in Syn1-Cre x Tsc1 fl/fl mouse. To study a synaptic dysregulation, we chose to study neuron-specific TSC1 knockout …
WebAug 14, 2024 · Animals. Mice carrying the Tsc1fl allele in the FVB/NJ background have been previous described 16.L-TKO mice were generated by crossing Tsc1 fl/fl (Stock no: 005680) and Alb-Cre (Stock no: 003574 ...
WebNov 1, 2014 · These mice were bred with Tsc1fl/fl to inactivate both Tsc1 alleles by Cre-mediated excision, thereby creating conditional knockout mice in which the Tsc1 gene was specifically disrupted in podocytes (podo-Tsc1−/−, genotype: Tsc1fl/fl, Cre+/−). The breeding protocol also generated heterozygous littermates ... chips wholesale paymentsWebfl oxed Tsc1 locus and used polyinosine-polycytidine (pIpC) treatment to induce deletion of TSC in the HSCs. Start-ing at 6 wk of age, we treated the Tsc1 fl /fl mx-1-cre + and the Tsc1 fl /fl mx-1-cre (control [Ctrl]) mice with pIpC every other day for 2 wk to delete the Tsc1 gene, which is hereby referred to as KO in the fi gures. chips whitbyWebFemale floxed Tsc1 mice (Tsc1FL/FL) containing LoxP sites flanking exons 17 and 18 of the Tsc1 gene were crossed with male osteocalcin (OC)-Cre mice, whose expression of Cre … chips wildeWebMay 1, 2013 · Results. The Tsc1fl/fl;AlbCre, Ptenfl/fl;AlbCre, and Tsc1fl/fl;Ptenfl/fl;AlbCre mice developed liver tumors that differed in size, number, and histologic features. Livers of Tsc1fl/fl;AlbCre mice did not develop steatosis; tumors arose later than in the other strains of mice and were predominantly hepatocellular carcinomas. Livers of the Ptenfl/fl;AlbCre … graphically challenged youtubeWebJul 14, 2024 · Multiple sclerosis (MS) is an inflammatory, demyelinating autoimmune disease of the central nervous system (CNS). Its pathophysiological processes lead to focal lesions in the brain, which are detectable using MRI. 1 Standard MRI protocols comprise native and contrast-enhanced T 1-weighted imaging, proton fluid attenuated inversion … graphically beautiful pc gamesWebMay 1, 2013 · Results. The Tsc1fl/fl;AlbCre, Ptenfl/fl;AlbCre, and Tsc1fl/fl;Ptenfl/fl;AlbCre mice developed liver tumors that differed in size, number, and histologic features. Livers … chips white houseWebPartial reduction of Raptor normalizes mTOR signaling in Tsc1-cKO cultures a Representative western blots (WB) from Tsc1fl/fl;Rptorfl/fl hippocampal cultures treated … chips window cleaning clevedon